![]() Penicillin covalently binds proteins spontaneously under physiologic conditions, enzymatic metabolism is not required.The bicyclic structure consists of a 4-member beta-lactam ring and a 5-member thiazolidine ring. Penicillin allergens are derived from the core ring structure.Immediate (72hrs) reaction, non-IgE-mediated, multiple underlying immunologic mechanisms.Levine classification based on the timing of symptom appearance.Produces contact dermatitis, maculopapular eruptions, eosinophilia, Stevens-Johnson syndrome, exfoliative dermatitis.Type IV, cell-mediated hypersensitivity.IgG- and IgM-mediated, soluble antigen-antibody complexes. ![]()
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